![]() ![]() “That disconnect between what was in the lab and what was in the clinic was of concern,” said Dr. In neuroscience, according to a review published in 2010, studies of male lab animals outnumbered female ones by a factor of five. In the decades since, women have made up close to half of clinical research participants, though they still lag behind in studies of certain drugs, like those used to treat cardiovascular disease and psychiatric disorders.īut a large sex gap persisted in basic science research using lab animals, studies that pave the way to medical breakthroughs. Women “ capable of becoming pregnant,” as the federal government put it, were largely excluded from clinical trials of drugs until 1993, when a new law required researchers funded by the National Institutes of Health to include women and minority groups. Women also may not derive the same benefits from the drugs. Women are almost twice as likely as men to experience severe side effects from drugs, most of which have dosages based on the initial testing done in men. The cost of excluding females - whether human or animal - from scientific research is high. The new research is “tipping all of these assumptions about sex differences and the influence of hormones on their head ,” said Rebecca Shansky, a behavioral neuroscientist at Northeastern University and a co-author of the new study. The study, published in the journal Current Biology on Tuesday, challenges century-old stereotypes that kept female animals out of laboratory research - and, until the 1990s, barred women from clinical trials. Male mice actually exhibited more erratic behavior than females did. Accounting for the hormonal changes was viewed as too cumbersome and too expensive.īut the estrous cycle has little to do with how female mice behave, according to a new study that used machine-learning software to track the second-to-second behavior of animals exploring an open space. The reason? Female mice, which experience a four- to five-day cycle of fluctuating ovarian hormones, were thought to be too complicated. Some of these areas will be updated with sounds during alpha support.For decades, male mice have been the default in scientific experiments that test new drugs or examine the connections of the brain. ![]() There’s also a lot of audio and related systems to cover, which means certain actions like modular group duplication, water bodies and guest crowds are silent. This is a temporary workaround until more time can be spent on improving it. We’ve implemented makeshift screen-space reflections for now, though you may notice missing data in areas that should be reflected as black. Additional Notesĭue to some issues we’ve disabled planar reflections until we can get them ready for general use. To report more issues or UX suggestions, please visit here. Paths can experience lots of visual artifacts, especially on slopes. Saving is still somewhat experimental! Please make multiple saves to ensure you do not lose progress.Ĭancelling actions can cause painted trees to disappear for a single frame. For more specific details, please refer to the GitHub. This is purely visual and does not alter the building mechanics.ĭue to its massive size, there can be unintended edge cases with the modular system. Modular grid visualization can become offset. Some terrain tools can be a little too quick at max intensity (raise, roughen).įorests can become overly dense at max brush intensity very quickly. Hard slope limits haven’t been introduced for terrain tools like raising and roughen, resulting in unnaturally sharp pillars or “spikes” if used excessively. This can be fixed by smoothing the slope. ![]() Painting water at different heights can cause slight water plane “bleeding” on large slopes when placed directly next to each other. IK issues can cause creatures to jitter or render their animations at a lower frame rate. ![]() Picking up and replacing the animal should fix them. Returning to a quadruped from a distance may cause its body IKs to briefly freak out.Ĭreatures may get stuck or stop moving. Though we are already aware of various issues in the build, we felt that these were the most pressing to notify alpha players about to prevent duplicate reports.Ĭertain slopes may cause quadrupeds to be angled weirdly. ![]()
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